The rates of incident malignancy were 25.3 events/1,000 person-years in the anti-TNF cohort and 38.3/1,000 person-years in the DMARD cohort, generating an age- and sex-adjusted incidence rate ratio of 0.58 (95% confidence interval 0.23–1.43) for the anti-TNF–treated cohort compared with the DMARD cohort. The gene discussed is TNF; the disease is cancer.