A risk classification system is commonly used to stratify advanced testicular cancer according to prognostic information [Table 1].[42] Good risk non-seminoma is disease without evidence of nonpulmonary visceral metastases and post-orchiectomy markers all of: AFP < 1,000 ng/mL, HCG < 5,000 iu/L, and LDH <1.5 × upper limit of normal. This evidence concerns the gene AFP and seminoma.