CD4 and neoplasm: Most experimental studies have shown that high intensity ultrasound did not enhance the potential risk of metastasis, and paradoxically the study of Wu[15] showed that a substantial number of tumor patients undergoing complete HIFU may present a negative conversion of circulating tumor-specific marker as marker of circulating tumor cells, and finally, the same group[16] showed in a clinical model that HIFU induced a positive antitumor immunity through activation of population of CD4+ lymphocytes.