INS and diabetes mellitus: Even though C-peptide is formed from pro-insulin and co-secreted with insulin, we should consider the possibility that C-peptide is a separate entity with biochemical and physiological characteristics that are different from those of insulin.[3, 4] C-peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and type 1 diabetes.[5, 6] The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes.