Since 25% of patients with end-stage renal disease (ESRD) have hypertension as the primary diagnosis[1] and moreover, microalbuminuria reflects endothelial damage which has been associated with increased cardiovascular mortality and morbidity, it becomes of paramount importance to study the effects of commonly used antihypertensive drugs like ACE inhibitor lisinopril and CCB-amlodipine on microalbuminuria and renal function in hypertension. This evidence concerns the gene ACE and hypertensive disorder.