Because IVB monotherapy reduces exudative changes, IVB might have a role in combination therapy with PDT.[18] In AMD, increased expression of VEGF has been reported in the CNV of eyes after PDT.[21] This elevated expression of VEGF following PDT might potentially increase the risk of CNV recurrences.[21] Similarly, the addition of IVB to PDT for PCV might counteract the up-regulation of VEGF following PDT and might prevent the recurrence of polyps. Here, VEGFA is linked to age-related macular degeneration.