The lower number of BMPR2 mutation carriers in the cohort from the New York Presbyterian Pulmonary Hypertension Center [5] could be explained by the fact that patients with a considered idiopathic PAH were not screened for large rearrangement of BMPR2. In the French PAH network, all patients with idiopathic or familial PAH were screened for point mutations and large rearrangements of BMPR2 gene, to avoid selection bias. This evidence concerns the gene BMPR2 and pulmonary hypertension.