Candidate genes reported as associated with SICH were involved in the pathways of the vessel wall integrity (ACE, APOE, neprilysin, endoglin, TGF-β1), endothelial dysfunction (ACE), inflammation markers (IL-6, TNF), and hemostasis (APOE, CD-14, Factor VII and XIII, VKORC1). Here, ACE is linked to endothelial dysfunction.