CRP has also been shown to significantly reduce cholesterol efflux from THP-1 (human myelogenous leukaemia cell line) and peripheral blood mononuclear cells to apoA-I or HDL.37 CRP also decreases the expression of ATP-binding membrane cassette transporter A1 (ABCA1) and ABCG1.38 The gene discussed is ABCG1; the disease is myeloid leukemia.