Based on the evidence supporting the role of inflammation in the pathogenesis of atherosclerosis, inflammatory markers have garnered substantial interest as markers of atherosclerotic risk and add to the information available from traditional measures such as lipid profiles.25,26 In the present study, the roles of CRP and TNF-α were evaluated as markers of the underlying inflammatory process in North Indian patients with acute myocardial infarction, and their serum levels were significantly elevated in the CAD-prone North Indian patients with AMI, compared to controls. The gene discussed is TNF; the disease is acute myocardial infarction.