The present study highlights significantly higher levels of inflammatory mediators such as CRP and TNF-α in the North Indian male patients with acute myocardial infarction, compared with control subjects, and a highly significant positive correlation between Lp(a) and TNF-α levels in male patients in the atherosclerosis-prone Indian population, clearly pointing to a role in the interplay of inflammation and dyslipidaemia in the pathogenesis of CAD in the atherosclerosis-prone North Indian population. The gene discussed is TNF; the disease is inherited lipid metabolism disorder.