Although we show here that p38α deletion in intestinal epithelial cells is linked with reduced chemokine expression and reduced immune cell recruitment to the lesions, we cannot fully exclude the possibility that for some pathogens, p38α is also related to the impairment of other immune functions in intestinal epithelial cells, as differential blocking of NF-κB pathway components during infection by different pathogens induced different host reactions. The gene discussed is NFKB1; the disease is infection.