Sequential cleavage of APP by β-secretase (BACE 1) and γ-secretase produces peptides of varying lengths (mainly 40 and 42 amino acids), collectively termed β-amyloid, or Aβ [5], [6], which is widely believed to be an acute mediator of cognitive impairment [7], as well as a causative factor in Alzheimer's disease (AD). This evidence concerns the gene APP and Alzheimer disease.