A subset of invasive breast cancer cases (n=150) was additionally analysed for protein level expression of the hypoxia-inducible (transcription) factors 1α and 2α (HIF-1α, HIF-2α), which are generally considered as the key regulators of the hypoxic response in cells and tissues, and their down stream targets GLUT1 and CAIX. Here, EPAS1 is linked to invasive breast carcinoma.