The pro-apoptotic effects of PLX4720 were found to be BRAF specific, with high levels (>30%) of apoptosis only induced in the BRAF-V600E-mutated melanoma cell line panel (WM35, WM164 and 1205Lu), and not the NRAS-mutated melanoma cell lines (WM1346, WM1361A and WM1366) (Supplementary Figure 1). Here, NRAS is linked to melanoma.