The report by Chan et al [32] is in agreement with our observations They found that obesity, dyslipidemia, IL-6, and TNF-α were the principal explanatory variables for the various components of the metabolic syndrome in Caucasian non-diabetic subjects, with IL-6 and TNF-α having different explanatory variables and effects [32]. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.