Wild type NRAS and BRAF melanoma cells (37-31E, MeWo) (Fig 1A), and melanoma cells harboring NRASQ61L (SKMel 147 and SKMel 103) (Fig 1B) showed a 50% inhibition of cell proliferation at 9.8 ± 0.4 μM, 18.9 ± 1.2 μM, 10.01 ± 0.2 μM and 21.2 ± 0.2 μM respectively, while the GI50 for BRAFV600E mutant cell lines was 6.1 ± 0.4 for UACC903 cells and 8.2 ± 0.3 for Colo 829 cells (Fig 1C). This evidence concerns the gene BRAF and melanoma.