Melanoma cell lines harboring wild type NRAS and BRAF (37-31E and MeWo), NRASQ61L mutation (SKMel 103 and SKMel 147) or BRAFV600E mutation (UACC903, Colo 829) were grown in complete medium and in the presence of increasing concentrations of MTA. The gene discussed is BRAF; the disease is melanoma.