Mice treated with MTA showed a significant decrease (47%) in the tumor volume (p < 0.001) compared with the controls (DMSO) (Fig 3A) with no evident toxic effects according to the mice weight (data not shown) and liver function tests (ALT(iu/L): control: 19 ± 2; MTA: 18 ± 3; AST(iu/L): control: 45 ± 4; MTA: 54 ± 3). This evidence concerns the gene GPT and neoplasm.