To examine a possible cause-effect relationship between the increase in HIF-1á and HO-1, BVR and H-ferritin levels observed in PSP-S samples, we first investigated whether the increased expression of HO-1, BVR, and H-ferritin was associated with increased nuclear expression of HIF-1α in the different in vitro experimental conditions. This evidence concerns the gene HIF1A and supranuclear palsy, progressive, 1.