HMOX1 and supranuclear palsy, progressive, 1: Therefore, our second aim was to examine the mechanism(s) involved in inducing HO-1, BVR and H-ferritin expression in PSP by analyzing the expression of and the roles of transcription factors involved in signaling events after hypoxia/reoxygenation and/or cigarette smoke exposure in the aforementioned lung biopsies and in vitro in a human monocyte/macrophage cell line (THP-1).