This study shows that the expression in lung macrophages of both the oxidative stress marker 4-HNE and antioxidant and anti-inflammatory proteins HO-1, BVR and H-ferritin is significantly higher in patients with PSP exposed to cigarette smoke (PSP-S) than in patients with condition and not exposed (PSP-NS) and in control patients. The gene discussed is HMOX1; the disease is supranuclear palsy, progressive, 1.