Eichler et al.[31] evaluated 83 BC patients with BM and concluded that HER-2 status was a strong predictor of survival in this population, with a reported prolonged survival of the HER62-positive population after the diagnosis of BM compared with HER-2-negative patients (17.1 months vs 5.2 months; P 5 .001). The gene discussed is ERBB2; the disease is breast cancer.