IL6 and psychiatric disorder: IL-6 increased significantly, which is consistent with other clinical studies [3]; further, other reports have noted an association of high levels of IL-6 (> 1 pg/mL) with painful events, surgical procedures and certain psychiatric disorders [19,20], as well as between fatigue and pain in animal models [21]; These findings suggests that IL-6 may regulates the clinical symptoms that develop in patients with FM.