The authors suggested that aberrant interaction of mutant ubiquitin C-terminal hydrolase L1 (UCH-L1) with the chaperone-mediated autophagy CMA machinery, at least partly accounted for the pathogenesis of PD associated with I93M UCH-L1 and the increase in the amount of α-synuclein [44]. The gene discussed is UCHL1; the disease is Parkinson disease.