It was found that CD147 and cyclophilin A (CypA) were both highly expressed in pancreatic cancer, and exogenous CypA promoted pancreatic cancer cell growth, which may be mediated through the interaction with its cellular receptor CD147 and the activation of ERK1/2 and p38 MAPKs [17]. The gene discussed is MAPK3; the disease is familial pancreatic carcinoma.