CCL2 and cancer: Considering the positive effects of AC-1041 on altering CCL2 and SNX16 expression, it is likely that these effects (angiogenesis and tumorigenesis inhibition by CCL2 repression, and epidermal growth factor receptor down-regulation by SNX16 induction) in addition to induction of ER stress pathways are important and specific for the biological effects of amino-trifluoro-phthalimides on cancer cells.