Clearly, an RTL therapy cannot substitute the antigen specific immunotherapeutic strategies aimed at activating the immune system to recognize and destroy tumour cells (e.g. cancer vaccine to stimulate p53-specific T cells using autologous dendritic cells pulsed with various HLA-A*0201 binding wild-type p53 derived peptides used in HLA-A2+ patients with progressive late-stage metastatic breast cancer [29]). This evidence concerns the gene TP53 and cancer.