Administration of streptozotocin caused rapid destruction of pancreatic β cells in rats, which led to impaired glucose-stimulated insulin release and insulin resistance, both of which are marked feature of type II diabetes.[20] The blood glucose-lowering effect of plant extracts is generally dependent upon the degree of pancreatic β-cell destruction and useful in moderate streptozotocin-induced diabetes.[21] The lesser the degree of pancreatic β-cell destruction, the more useful the herb is in treating diabetes in animals. This evidence concerns the gene INS and diabetes mellitus.