APP and Alzheimer disease: These models recapitulate, at least to some extent, aspects of human AD pathology, including Abeta plaque deposition [97, 98], defective axonal transport [99, 100] and axonopathies [101], mitochondrial mislocalisation [102], defects in synaptic plasticity [103] and progressive locomotor deficits [98], affected life-span [97, 98, 104], and age-dependent neurodegeneration including vacuolization of the brain [97, 98, 105].