The obesity-risk-allele score based on genotypes at eight SNPs associated with childhood BMI (in/near to: FTO, MC4R, TMEM18, GNPDA2, NEGR, KCTD15, BDNF, and ETV5) ranged from 2 to 15 alleles. The gene discussed is TMEM18; the disease is obesity due to melanocortin 4 receptor deficiency.