In addition, we found a higher proportion of positive responders after TC compared with IM immunization, as depicted in Figure 1 (upper panels) (χ2 test, H3 p = 0.02, H1 p = 0.035, NP p = 0.035) for influenza-specific CD8 but not CD4 responses (Fig 2, lower panels). The gene discussed is CD4; the disease is influenza.