Even though it did not induce EAE, the lymphocytic reaction of both B and T cells to Aβ is potentially pathogenic because of the risks of meningoencephalitis [59], entry of cytotoxic CD8 T cells into the brain, strong proinflammatory cytokine profile of the CD4-T cells [60], and brain hemorrhages caused by Aβ antibodies [61], [62], [63]. This evidence concerns the gene CD4 and meningoencephalitis.