Marcel et al. (2009) demonstrated that, in a group of 32 cancer-affected Brazilian patients with LFS or Li-Fraumeni−like syndrome and a germline p53 mutation, the presence of a G allele was associated with a 12.5-year earlier diagnosis (GG/GT 26.3 years versus TT 38.8; P = 0.06) [12]. The gene discussed is TP53; the disease is cancer.