ISL1 and coronary artery disorder: We then delineated the patterns of risk in these populations by using the expectation maximization (EM) method to estimate haplotypes and risk of CHD from the 6 ISL1-flanking SNPs (rs6867206, rs4865656, rs6869844, rs2115322, rs6449600, rs6449612) and the 3 SNPs within ISL1 (rs3762977, IVS1+17C>T, rs1017).