NQO1 and cancer: Despite this, the main enzymes involved in quinone metabolism in human cells belong to the NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family and, with respect to binaphthoquinone metabolism, may function similarly to NDE1. For example, in last two decades, attention has been given to beta-lapachone, an ortho-naphtoquinone antineoplastic drug, and other quinone based drugs which take advantage of NQO1 overexpression in human cancers and selectively target them [34], [35], [36], [37].