IMP3 and hepatocellular carcinoma: U3 small nucleolar ribonucleoprotein (IMP3) and protein kinase C alpha (PRKCA) had been previously linked to aggressiveness and metastasis in a variety of tumor types, including breast, colon, renal cell, lung, ovarian, and hepatocellular cancer [33], [34], [35], [36], [37], [38].