The authors also proved byusing an open field test that elevated anxiety, which often correlates withhigh locomotor activity and rearing, and deficits in contextual habituationdoes not attribute to deficits in behavioral learning in the here usedclock-gene-knockout mice: Cry1,2-knockout mice showedfacilitated habituation in parallel to elevated levels of anxiety, while Bmal1-knockoutmice showed deficits in contextual habituation at significantly lower anxietylevels. This evidence concerns the gene BMAL1 and Anxiety.