IFNG and infection: Alternatively, deficiency of IL-10 in our system could bypass the requirement for IL-17A and CXCL10 production and enhanced Th1 influx into the lung, resulting in subsequent protection against Mtb. To test this, IL-17 was neutralized in mice via use of a mAb before and during infection with Mtb, and effects on IFN-γ and CXCL10 production and cellular influx into the lung were examined.