Similar to the other cancers (Oba-Shinjo et al, 2005; Unoki et al, 2009), UHRF1 expression was associated with the malignant nature of lung cancer in Japanese cases (Table 2); UHRF1 high expression was significantly correlated with pT factor (higher in advanced stage; P=0.00010 by χ2 test) and pN factor (higher in cancers with metastasis in regional lymph nodes; P=0.00018 by χ2 test). Here, UHRF1 is linked to cancer.