IGF1 and kidney cancer: As shown in Figure 1, the multivariable-adjusted odds ratios (ORs) and 95% confidence interval (CIs) for kidney cancer for increasing quartiles of IGF-I were 0.40 (0.20–0.79), 0.39 (0.19–0.81), and 0.40 (0.18–0.90) compared with the low-quartile reference category.