S100A4 and cancer: S100A4 gene overexpression has been related to the malignant potential of some tumors [10] and has been closely associated with metastasis in several human cancers, including colorectal [21], breast [22,23], ovary [24], thyroid [25], pancreatic [26], lung [27,28], esophageal [29], prostate [30] and gastric cancer [31,32].