Further analysis is required to demonstrate a direct interaction between TCF/LEF1 transcription factors with the promoter regions of these genes in response to the activated Wnt/β-catenin, but the predictions made by the proposed CART method revealed a strong connection between the canonical Wnt pathway and the cooperative control of gene transcription in brain physiology and neuropathology, in particular AD. The gene discussed is HNF4A; the disease is Alzheimer disease.