ITPK1 and Alzheimer disease: In fact, other genes involved in inositol metabolism, phosphatidylinositol (4,5) bisphosphate 5-phosphatase A (PIB5PA), or in phosphatidylinositol signaling, as inositol 1,3,4-triphosphate 5/6 kinase (ITPK1) and phosphoinositide-3-kinase regulatory subunit 3γ (PIK3R3), were identified by our method, which is consistent with the potential connection between AD and phosphoinositides [63].