Iqbal et al. have suggested that the significance of Bcl-2 should be assessed within the context of DLBCL subgroups because of the controversy surrounding its prognostic significance.14 Some authors have correlated Bcl-2 expression with high-risk DLBCL.17 In our report, we observed Bcl-2 expression in 37% of our patients with high-risk DLBCL and we did not demonstrate any prognostic significance regarding the remission rate, even though the P-value was close to statistical significance (P = 0.07). The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.