To determine whether this is cell type-specific, the effect of Reptin depletion on hTERT mRNA expression was further evaluated in cervical cancer cell lines including HeLa and SiHa and we obtained identical decline in hTERT mRNA as seen in gastric cancer cells (Fig. 1B, control vs Reptin siRNA, P < 0.01). The gene discussed is RUVBL2; the disease is cervical carcinoma.