After 48 hours, the Ang-2/Ang-1 ratio was higher in patients that developed septic shock (10.58, range 0.10-101.70) compared to patients with non-complicated sepsis (0.40, range 0.01-18.70), but statistical significance was not reached (Mann-Whitney test: P = 0.06) (Figure 2). This evidence concerns the gene ANGPT1 and septic shock.