In our population, a median Ang-2/Ang-1 ratio of 1.17, which was the optimal cut-off value identified by the ROC procedure, predicted the development of septic shock with a sensitivity of 77.8% (95%CI = 40.0%-97.2%) and a specificity of 60% (95% CI = 40.6%-77.3%). The gene discussed is ANGPT1; the disease is septic shock.