ANGPT1 and Decreased total neutrophil count: To determine the relationship of angiopoietin levels with 30-day mortality, we initially performed univariate Cox proportional hazards analysis, in which the following variables were found to be statistically significant: age, duration of neutropenia, SOFA, MASCC, Ang-2 (48 hours after fever) and Ang-2/Ang-1 ratio (both at fever onset and 48 hours thereafter).