To determine if NSCLC binding to soluble recombinant TGFBI also contributed to improved responses to chemotherapy, we analyzed caspase 3/7 activation in NSCLC cells exposed to 20 μg/mL rh-TGFBI and treated with etoposide at a concentration of 5 μM and 50 μM for A549 cells and H1299 cells, respectively. This evidence concerns the gene CASP3 and non-small cell lung carcinoma.