Therefore, to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy, we incubated NSCLC cells with a blocking antibody specific for αvβ3, 1 h before the addition of rh-TGFBI (20 μg/mL) for 24 h and an further exposure to etoposide (5 μM for A549 cells and 50 μM for H1299 cells) for additional 24 h. This evidence concerns the gene TGFBI and non-small cell lung carcinoma.