Previous studies were unable to find association between IBD and the IL-10 promoter polymorphisms [22,31,35,39,40] whereas other studies have found associations between paediatric onset of CD and IL-10 C-819T wildtype allele [30], Crs2222202T variant allele [30] and between the IL-10 G-1082A variant allele and risk of UC [58] (Table 4). The gene discussed is IL10; the disease is Cowden disease.