In the present study, we have replicated the associations between seven SNPs (CDKAL1-rs10946398, IGF2BP2-rs4402960, SLC30A8-rs13266634, CDKN2A/B-rs10811661, HHEX-rs5015480, FTO-rs8050136, and KCNQ1-rs2237892) with T2D in the Chinese Han population living in China, and an association between WFS1-rs6446482 with early-onset T2D was also identified in the subgroup analysis. This evidence concerns the gene CDKAL1 and type 2 diabetes mellitus.