Overall, the pooled ORs for T2D were significant for HHEX-rs5015480 (pooled OR,1.24; p < 0.00001), IGF2BP2-rs4402960 (pooled OR, 1.14; p = 0.0002), TCF2-rs7501939 (pooled OR, 1.16; p < 0.00001), FTO-rs8050136 (pooled OR, 1.17; p < 0.00001), WFS1-rs6446482 (pooled OR, 1.26; p = 0.009), CDKAL1-rs10946398 (pooled OR, 1.24; p < 0.00001), SLC30A8-rs13266634 (pooled OR, 1.19; p < 0.00001), CDKN2A/B-rs10811661 (pooled OR, 1.28; p < 0.00001), and KCNQ1-2237892 (pooled OR, 1.33; p < 0.00001). The gene discussed is HHEX; the disease is type 2 diabetes mellitus.