WFS1 and type 2 diabetes mellitus: Prompted by this observation, we performed a subgroup analysis of 406 early-onset T2D patients (age of diagnosis ≦45 years) and 973 control subjects, showing that WFS1- rs6446482 was significantly associated with early-onset T2D (risk allele-specific OR, 1.96; 95% CI, 1.05-4.76; nominal p = 0.03; empiric p = 0.03) after adjustment for gender, age, and BMI.