TSPAN8 and type 2 diabetes mellitus: However, the remaining six genetic loci were identified by meta-analysis of GWAS, including JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30, and MTNR1B, of which only MTNR1B in one study was shown to increase the risk for T2D and an increased fasting plasma glucose concentration in the Chinese Han [12,41].