The sensitivity towards ICL-agents was clearly dissimilar between the FA pathway-proficient cell line panel and FANCC-deficient HuH-7 cells, with the latter displaying a distinct hypersensitivity (inhibitory concentration 50% (IC50) ratios [40] ranging between 3.4 to 18.6 as compared to the other HCC lines) (Fig. 4A, upper panel). This evidence concerns the gene FANCA and hepatocellular carcinoma.