FANCC and neoplasm: According to proposed evaluation models for the identification of LOH events where no matching normal tissue is available, these data are strongly suggestive (although not definitely evidentiary) of allelic loss of one copy of chromosome 9q including the non-mutated FANCC allele in the original tumor (or its precursor cells), followed by repeated duplication of the remaining chromosome 9q, including the mutated FANCC allele, later on [48-50].