On the other hand, mono-allelic germline mutations of distal FA pathway genes, such as FANCD1, FANCN or FANCJ, confer low to medium penetrance susceptibility for breast/ovarian cancer [12,13,53] and, as applies to FANCD1 and FANCN, also for pancreatic cancer [15,54-57]. Here, BRIP1 is linked to familial pancreatic carcinoma.