The occurrence of an FA-associated FANCC mutation in HCC could also denote a tissue-specific susceptibility for the development of HCC in FA patients; The majority of solid malignancies seen in FA patients consists of head and neck or gynaecologic carcinomas (5.3%), as reported in a large meta-analysis of 1300 cases [60], but also 2.8% of all FA patients developed liver tumors. The gene discussed is FANCC; the disease is Friedreich ataxia.