VEGFA and neoplasm: Thus, an increase in angiogenesis appears to be the main mechanism of growth-promoting effects of NE and E. Indeed, in various cancer cell types, such as ovarian cancer, colon cancer, melanoma, pharyngeal carcinoma, and multiple myeloma, activation of β-ARs present on tumor cells led to a dramatic increase in synthesis and release of angiogenic factors—VEGF, IL-8, and IL-6 [5, 16, 20–23].