It has been shown that MM cells are capable of secreting VEGF in response to IL-6 stimulation, and in response to this VEGF stimulation, microvascular endothelial cells and bone marrow stromal cells in turn secrete IL-6, a potent growth factor for malignant plasma cells, thus closing a paracrine loop [84, 85]. The gene discussed is IL6; the disease is Miyoshi myopathy.