Several studies suggested that angiogenesis plays an important role, as might autocrine and paracrine VEGF/VEGFR-related loops in hemato-lymphoid malignancies such as acute and chronic leukemias, myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), lymphomas, and multiple myeloma (MM) [29–39] (Figure 1). This evidence concerns the gene VEGFA and plasma cell myeloma.