C-reactive protein previously has been proposed to correlate with the extent of atherosclerosis.38,39 Studies have shown that lower profile plaques are more numerous than “significant stenoses” and therefore, are statistically more likely to lead to plaque rupture than the relatively few lesions of ≥70% stenosis.40 Thus, it is possible that an elevated CRP simply represents a more diffuse process of coronary atherosclerosis with a higher total plaque burden. The gene discussed is CRP; the disease is atherosclerosis.