No significant differences were found in any of the variables studied (age, cardiovascular risk factors such as smoking, hypertension, diabetes, dyslipemia, COPD, plasma homocystein levels, lipidic profile or serum creatinine levels—a renal failure marker) that could act as confounding factors in the study of the association between CRP plasma levels and clinical severity of PAD. This evidence concerns the gene CRP and peripheral arterial disease.