CRP and peripheral arterial disease: However, this relationship reinforces the important role of the inflammatory pathway in the form of presentation of PAD in the symptomatic states and not just in the case of underlying asymptomatic disease, where CRP is well-known as a predictor and marker of developing peripheral vascular disease.19–24 The second limitation is that the long-term effects of the surgical procedures, as could be in case of the inflammatory changes at anastomotic sites, would be able to elevate the CRP plasma levels.