For instance, in vivo, treatment of tumor-bearing animals with interleukin-12 (IL-12) shifts tumor-associated macrophages from a dominant M2 profile (elevated expression of TGFβ, IL-10, and MCP1) to a proimmunogenic/inflammatory M1 profile (elevated expression of IL-6 and TNFα) [33]. This evidence concerns the gene IL6 and neoplasm.