INS and hypertensive disorder: Given the recent findings that HO inducers enhance insulin sensitivity and improve glucose metabolism in different insulin resistant rats strains including ZDF and GK [219, 220] and obese mouse [40, 111, 113], it is tempting to speculate that the HO-mediated suppression of macrophage infiltration constitutes not only an important anti-inflammatory mechanism to limit tissue insult in hypertension but also a mechanism that could be explored to improve insulin sensitivity and glucose metabolism in obsessed individuals with insulin resistance and overt T2D.