We recently showed that upregulating the HO system with hemin suppressed NF-κB in different models of T2D including ZDF and GK rats [42–44], as well as different hypertensive models including SHR [47, 84] and DOCA-hypertensive rats [48, 65, 84, 150, 151]. Here, HMOX1 is linked to type 2 diabetes mellitus.