Thus, the insulin-sensitizing effects of hemin, when combined to its antihypertensive effects [58, 59, 63–65, 83–85, 148–154], underscores the important role of the HO system that could be explored against impaired glucose metabolism and hypertension given the rising incidence of comorbidities of essential hypertension, glucose intolerance, and insulin resistance [155, 156] as well as pathophysiological conditions like primary aldosteronism, glucose intolerance, and insulin resistance [157–159]. Here, INS is linked to primary aldosteronism.