Further revelations from our findings indicate that hemin therapy is also effective against streptozotocin- (STZ-) induced diabetes [41] and improves insulin sensitivity/glucose metabolism in spontaneously hypertensive rats (SHRs) [47], a model of essential hypertension and with features of metabolic syndrome like insulin resistance and impaired glucose metabolism [138, 139]. The gene discussed is INS; the disease is essential hypertension.