Insulin insensitivity is a hallmark of T2D [123, 124] the causes include excessive NF-κB activity [125–129], elevated JNK activation [100] and increased production of adipokines including free fatty acids, TNFα, ILs, resistin, leptin by the adipose tissue [130–133]. This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.